Blastic natural killer (NK) cell leukemia (agranular CD4+CD56+ leukemia).
نویسندگان
چکیده
Blastic NK cell lymphoma is a rare hematolymphoid neoplasm. This report illustrates an unusual presentation of this entity, namely as a primary leukemia, but without skin lesions.
منابع مشابه
TCL1 and CLA expression in agranular CD4/CD56 hematodermic neoplasms (blastic NK-cell lymphomas) and leukemia cutis.
Agranular CD4/CD56 hematodermic neoplasm (CD4/CD56 HN), also termed blastic natural killer cell lymphoma, is characterized by a peculiar immunophenotype and high skin tropism. The lineage of origin is not known, and a plasmacytoid dendritic cell derivation has been proposed. CD4/CD56 HN generally is diagnosed by using tumor skin biopsy, with the most important differential diagnosis being myelo...
متن کاملPrimary cutaneous blastic natural killer cell lymphoma.
Sir, Blastic natural killer-cell lymphoma, also called “agranular CD4+ CD56+ haematodermic neoplasm” is an uncommon type of tumour, which is included in the new World Health Organization (WHO) classification as a malignancy derived from natural killer (NK) cells. It is very aggressive, affecting many organs, and skin involvement is highly characteristic. Several origins have been proposed, but ...
متن کامل[Retrospective analysis of 4 cases of the so-called blastic NK-cell lymphoma, with reference to the 2008 WHO classification of tumours of haematopoietic and lymphoid tissues].
OBJECTIVE To study the clinical and pathologic features of 4 cases of the so-called blastic natural killer (NK)-cell lymphoma, with reference to the 2008 WHO classification of tumours of haematopoietic and lymphoid tissues. METHODS The clinical, pathologic and immunohistochemical findings (EliVision method) of 4 cases of blastic NK-cell lymphoma (previously diagnosed according to the 2001 WHO...
متن کاملBlastic NK-Cell Leukemia / Lymphoma
Blastic natural killer (NK) cell lymphoma / leukemia is a rare NK cell malignancy of unknown etiology. It occurs in multiple sites and with a propensity for skin involvement. We report such a case in a 35-year-old male suffering from erythematous and purpuric papules and plaques on his face and trunk for 6 months. A biopsy specimen of the skin showed diffuse infiltration of blastlike lymphoid c...
متن کاملCD56+/CD4+ lymphomas and leukemias are morphologically, immunophenotypically, cytogenetically, and clinically diverse.
CD56, a neural adhesion molecule, is a marker of natural killer (NK) lymphocytes as well as a subgroup of CD8+ T cells. Normal lymphocytes with a CD56/CD4 phenotype are scarce. Physiologic increases may occur in patients with immunosuppression, chronic inflammation, and autoimmune disorders. We report 4 cases of lymphomas/leukemias with the unusual CD56/CD4 phenotype. Two were of T-cell and 2 o...
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عنوان ژورنال:
- Annals of clinical and laboratory science
دوره 36 2 شماره
صفحات -
تاریخ انتشار 2006